publicaciones

The burden of premature coronary heart disease among adults with low socioeconomic status in Argentina: A modeling study

M Victoria Salgado, Joanne Penko, Alicia Fernández, Francine Rios-Fetchko, Pamela G Coxson, Raúl Mejia  Abstract Background The well-established inverse relationship between socioeconomic status (SES) and risk of developing coronary heart disease (CHD) cannot be explained solely by differences in traditional risk factors. Objective To model the role SES plays in the burden of premature CHD in Argentina.

The burden of premature coronary heart disease among adults with low socioeconomic status in Argentina: A modeling study Leer más »

Smoking patterns by birth cohort in Argentina: an age-period-cohort population-based modeling study

M. Victoria Salgado, Yoonseo Mok,Jihyoun Jeon, Mohammed Jaffri, Jamie Tam, Theodore R. Holford, Luz M. Sánchez-Romero, Rafael Meza, and Raul Mejia Summary Background Argentina’s smoking rates remain high. We aim to estimate Argentina age-specific histories of smoking initiation, cessation, prevalence, and intensity by birth-cohort to inform policy interventions.

Smoking patterns by birth cohort in Argentina: an age-period-cohort population-based modeling study Leer más »

Evolutionary and functional analyses of LRP5 in archaic and extant modern humans

Neus Roca-Ayats, Iago Maceda, Carlos David Bruque, Núria Martínez-Gil, Natàlia Garcia-Giralt, Mónica Cozar, Leonardo Mellibovsky, Wim Van Hul, Oscar Lao, Daniel Grinberg, Susanna Balcells Abstract Background The human lineage has undergone a postcranial skeleton gracilization (i.e. lower bone mass and strength relative to body size) compared to other primates and archaic populations such as the Neanderthals. This gracilization has been traditionally explained by diferences in

Evolutionary and functional analyses of LRP5 in archaic and extant modern humans Leer más »

wiley

Positive selection in gamete interaction proteins in Carnivora

Francisco Pisciottano, María Clara Campos, Clementina Penna, Carlos David Bruque, Toni Gabaldón, Patricia Saragüeta  Abstract The absence of robust interspecific isolation barriers among pantherines, including the iconic South American jaguar (Panthera onca), led us to study molecular evolution of typically rapidly evolving reproductive proteins within this subfamily and related groups. In this study, we delved into the evolutionary forces acting

Positive selection in gamete interaction proteins in Carnivora Leer más »

elsevier

From in-silico screening to in-vitro evaluation: Enhancing the detection ofMicrocystins with engineered PP1 mutant variants

Ezequiel J. Alba-Posse, Carlos David Bruque, Yamila Gandola, Javier Gasulla, Alejandro D. Nadra Abstract Cyanotoxins produced during harmful algal blooms (CyanoHABs) have become a worldwide issue of concern. Microcystins (MC) are the most ubiquitous group of cyanotoxins and have known carcinogenic and hepatotoxic effects. The protein phosphatase inhibition assays (PPIAs), based on the inhibition of

From in-silico screening to in-vitro evaluation: Enhancing the detection ofMicrocystins with engineered PP1 mutant variants Leer más »

springer

The Beta2‐adrenergic agonist salbutamol synergizes with paclitaxelon cell proliferation and tumor growth in triple negative breast cancermodels

Martina Jabloñski, María Sol Rodríguez, Ezequiel Mariano Rivero, Carlos David Bruque, Silvia Vanzulli, Ariana Bruzzone, Cecilia Pérez Piñero, Isabel Alicia Lüthy Abstract Purpose: Globally breast cancer accounts for 24.5% in incidence and 15.5% in cancer deaths in women. The triple-negative subtype lacks any specific therapy and is treated with chemotherapy, resulting in significant side-effects. We aimed to investigate if the dose of

The Beta2‐adrenergic agonist salbutamol synergizes with paclitaxelon cell proliferation and tumor growth in triple negative breast cancermodels Leer más »

free-full-text-medicina

DISPARITIES IN REGIONAL OBESITY RATES IN ARGENTINA BY SOCIOECONOMIC STATUS

FRANCINE RÍOS-FETCHKO, ALICIA FERNÁNDEZ, RAÚL MEJÍA, M. VICTORIA SALGADO Abstract Background: Obesity rates in Latin America are increasing overall and among people with low socio-economic status (SES). Obesity and SES disparities can vary by region-a valuable indicator of local drivers. The objective of this study was to examine regional and SES differences in obesity in

DISPARITIES IN REGIONAL OBESITY RATES IN ARGENTINA BY SOCIOECONOMIC STATUS Leer más »

csiro

Expression and characterisation of Fmr1 splice variants duringfolliculogenesis in the rat

Ianina C. Ferder, Lucía D. Espeche, Carlos D. Bruque, Fernanda Parborell, Marta Tesone and Liliana Dain Abstract Context: The FMR1 gene consists of 17 exons and codes for the FMRP protein. FMR1 is involved in four genetic disorders depending on the CGG repeats length in its 5’UTR: the full mutation is responsible for the Fragile X

Expression and characterisation of Fmr1 splice variants duringfolliculogenesis in the rat Leer más »

mdpi

Genetic Analysis Algorithm for the Study of Patients withMultiple Congenital Anomalies and Isolated CongenitalHeart Disease

Marisol Delea, Lucia S. Massara, Lucia D. Espeche, María Paz Bidondo, Pablo Barbero, Jaen Oliveri, Paloma Brun, Mónica Fabro, Micaela Galain, Cecilia S. Fernández, Melisa Taboas, Carlos D. Bruque, Jorge E. Kolomenski, Agustín Izquierdo, Ariel Berenstein, Viviana Cosentino, Celeste Martinoli, Mariana Vilas, Mónica Rittler, Rodrigo Mendez, Lilian Furforo, Rosa Liascovich, Boris Groisman, Sandra Rozental, Liliana

Genetic Analysis Algorithm for the Study of Patients withMultiple Congenital Anomalies and Isolated CongenitalHeart Disease Leer más »

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