The Beta2‐adrenergic agonist salbutamol synergizes with paclitaxelon cell proliferation and tumor growth in triple negative breast cancermodels

Martina Jabloñski, María Sol Rodríguez, Ezequiel Mariano Rivero, Carlos David Bruque, Silvia Vanzulli, Ariana Bruzzone, Cecilia Pérez Piñero, Isabel Alicia Lüthy

Abstract

Purpose: Globally breast cancer accounts for 24.5% in incidence and 15.5% in cancer deaths in women. The triple-negative subtype lacks any specific therapy and is treated with chemotherapy, resulting in significant side-effects. We aimed to investigate if the dose of chemotherapeutic drugs could be diminished by co-administering it with the β2-agonist salbutamol.

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